Phosphorus tribromide → HCID 22759278, Verbindung

HRID 1704350Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1704350
P(Br)(Br)[Br:2].[C:5]([O:8][CH:9]([CH2:14][O:15][C:16]1[CH:21]=[CH:20][C:19]([F:22])=[CH:18][CH:17]=1)[C:10]#[C:11][CH2:12]O)(=[O:7])[CH3:6]>CCOCC>[C:5]([O:8][CH:9]([CH2:14][O:15][C:16]1[CH:21]=[CH:20][C:19]([F:22])=[CH:18][CH:17]=1)[C:10]#[C:11][CH2:12][Br:2])(=[O:7])[CH3:6]

Komponenten

4

Edukt 2

HCID 24614Phosphorus tribromideHCID 22759281HCID 22759281, Verbindung

Produkt 1

HCID 22759278HCID 22759278, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 3283Diethyl EtherLösungsmittel

Versuchsvorschrift

Phosphorus tribromide (10.6 g., 0.039 mole) is added dropwise during 15 minutes to a solution of 4-acetoxy-5-(4-fluorophenoxy)-2-pentyn-1-ol (25.1 g., 0.10 mole) in ether (80 ml.). The resulting solution is stirred at room temperature for 1 hour and then heated at reflux for 30 minutes. The solution is poured into 100 ml. of ice water. The organic layer is separated, washed with water and dried over Na2SO4. The solvent is evaporated under reduced pressure to leave the title compound as a light yellow oil.

Aufarbeitung

  1. temperatureheated
  2. temperatureat reflux for 30 minutes
  3. additionThe solution is poured into 100 ml
  4. customThe organic layer is separated
  5. washwashed with water
  6. dry with materialdried over Na2SO4
  7. customThe solvent is evaporated under reduced pressure

Quellen und Nachweise

ORD-Eintrag
ord-f5928c9c460344d4aeec001721cc4f8e
Quelldatensatz
uspto-grants-1978_11
Patentnummer
US04126629

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