Acetic Acid → HCID 12468024, Verbindung

HRID 1704643Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1704643
[Cl:1][C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][CH:10]=1)[C:7]1=[N:11][C:12]([CH3:14])=[N:13][N:6]1[C:5]2([C:16]1[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=1)N.C(O)(=[O:24])C>CO>[Cl:1][C:2]1[CH:10]=[CH:9][C:8]([C:7]2[N:11]=[C:12]([CH3:14])[NH:13][N:6]=2)=[C:4]([CH:3]=1)[C:5]([C:16]1[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=1)=[O:24]

Komponenten

4

Edukt 2

HCID 176Acetic AcidHCID 124680237-Chloro-2-methyl-5-phenyl-5H-[1,2,4]triazolo[5,1-a]isoindol-5-amine

Produkt 1

HCID 12468024HCID 12468024, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 887MethanolLösungsmittel

Versuchsvorschrift

Ten milligrams of 7-chloro-2-methyl-5-phenyl-5H-[1,2,4]triazolo-[5,1-a]-isoindol-5-amine (as prepared in Example 1) are refluxed for 10 minutes in 2 ml of 50% aqueous methanol containing a drop of acetic acid. The methanol is removed under vacuum and the aqueous residue made basic with 10% NaOH. The aqueous solution is washed with chloroform, neutralized with 10% HCl and extracted with chloroform. The chloroform solution is evaporated to dryness and the residue is recrystallized from a water-ethanol mixture, m.p. 149° to 150°.

Aufarbeitung

  1. customThe methanol is removed under vacuum
  2. washThe aqueous solution is washed with chloroform
  3. extractionextracted with chloroform
  4. customThe chloroform solution is evaporated to dryness
  5. customthe residue is recrystallized from a water-ethanol mixture, m.p. 149° to 150°

Quellen und Nachweise

ORD-Eintrag
ord-0ef3825a6c99435f97e2425fff98bfb6
Quelldatensatz
uspto-grants-1978_11
Patentnummer
US04127587

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