C(O[C:4]1[C:5](O)=[C:6]([C:9]([N+:12]([O-:14])=[O:13])=[CH:10][CH:11]=1)[CH:7]=[O:8])C.[CH2:16](Cl)[C:17]1[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=1.[C:24](=[O:27])([O-])[O-].[K+].[K+].[OH2:30].[CH3:31]N(C)C=O>>[CH2:16]([O:30][C:9]1([N+:12]([O-:14])=[O:13])[C:10]([O:27][CH2:24][CH3:31])=[CH:11][CH:4]=[CH:5][CH:6]1[CH:7]=[O:8])[C:17]1[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=1A mixture of 3-ethoxy-2-hydroxy-6-nitrobenzaldehyde (58 g, 0.275 mole), benzyl chloride (34.8 cm3 0.302 mole) and potassium carbonate (41.7 g, 0.302 mole) in 300 cm3 of dimethylformamide is heated for 3 hours under reflux with stirring. The reaction mixture is poured into 1 litre of iced water and the precipitate is filtered off. It is washed with water and dried. A light beige powder of 2-benzyloxy-3-ethoxy-2-nitrobenzaldehyde (72 g, yield =86%, m.p. =110°-111° C.) is obtained.
Wird geladen…
