Water → N-[2-(4-Methoxyphenyl)propyl]acetamide

HRID 1709275Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1709275
[NH2:1][CH2:2][CH:3]([C:5]1[CH:10]=[CH:9][C:8]([O:11][CH3:12])=[CH:7][CH:6]=1)[CH3:4].O.C(=O)(O)[O-].[Na+].[C:19](Cl)(=[O:21])[CH3:20]>C(OCC)(=O)C>[C:19]([NH:1][CH2:2][CH:3]([C:5]1[CH:6]=[CH:7][C:8]([O:11][CH3:12])=[CH:9][CH:10]=1)[CH3:4])(=[O:21])[CH3:20]

Komponenten

6

Edukt 4

HCID 962WaterHCID 6367Acetyl chlorideHCID 2026252-(4-Methoxyphenyl)propan-1-amineHCID 516892Sodium Bicarbonate

Produkt 1

HCID 14579484N-[2-(4-Methoxyphenyl)propyl]acetamideAusbeute 99,8 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 8857Ethyl AcetateLösungsmittel2×

Versuchsvorschrift

A mixture of 19.8 g of 1-amino-2-(4-methoxyphenyl)propane, 200 ml of ethyl acetate, 200 ml of water and 84 g of sodium bicarbonate is cooled at 5° to 10° C. under stirring, and 18.8 g of acetyl chloride in 100 ml of ethyl acetate are added dropwise thereto at the same temperature. After the reaction, the ethyl acetate layer is separated therefrom, washed, dried and then condensed to dryness under reduced pressure. 24.8 g of 1-acetylamino-2-(4-methoxyphenyl)propane are obtained as oil.

Aufarbeitung

  1. temperatureis cooled at 5° to 10° C.
  2. customAfter the reaction
  3. customthe ethyl acetate layer is separated
  4. washwashed
  5. customdried
  6. customcondensed to dryness under reduced pressure

Quellen und Nachweise

ORD-Eintrag
ord-22b1727281c84c45b1f4c781668f8386
Quelldatensatz
uspto-grants-1990_08
Patentnummer
US04948810

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