HCID 86744189, Verbindung → Pirazolac

HRID 1710200Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1710200
[F:1][C:2]1[CH:7]=[CH:6][C:5]([N:8]2[CH:12]=[C:11]([C:13]3[CH:18]=[CH:17][C:16]([Cl:19])=[CH:15][CH:14]=3)[C:10]([CH2:20][C:21]([O-:23])=[O:22])=[N:9]2)=[CH:4][CH:3]=1>[Pd]>[F:1][C:2]1[CH:3]=[CH:4][C:5]([N:8]2[CH:12]=[C:11]([C:13]3[CH:18]=[CH:17][C:16]([Cl:19])=[CH:15][CH:14]=3)[C:10]([CH2:20][C:21]([OH:23])=[O:22])=[N:9]2)=[CH:6][CH:7]=1

Komponenten

3

Edukt 1

HCID 86744189HCID 86744189, Verbindung

Produkt 1

HCID 51222Pirazolac

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 23938PalladiumKatalysator

Versuchsvorschrift

1,49 Grams (3 mM) of the benzohydryl [1-(4-fluorophenyl)-4-(4-chlorophenyl)-1H-pyrazol-3-yl]-acetate are dissolved in 40 ml of tetrahydroflurane. To the solution 0,4 g of Pd on charcoal (10%) are added, then the mixture is hydrogenated at room temperature and pressure. At the end of the reaction the catalysator is filtered, the solvent evaporated and the product crystallized from acetic acid/ethanol. The title product is obtained in almost quantitative yield.

Aufarbeitung

  1. customis hydrogenated at room temperature
  2. customAt the end of the reaction the catalysator
  3. filtrationis filtered
  4. customthe solvent evaporated
  5. customthe product crystallized from acetic acid/ethanol

Quellen und Nachweise

ORD-Eintrag
ord-f2ab52f269b44a928d2852f75c3558b9
Quelldatensatz
uspto-grants-1990_08
Patentnummer
US04952702

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