Dimethylformamide dimethyl acetal → N'-(3-Ethyl-2,6-dioxo-1,2,3,6-tetrahydropyrimidin-4-yl)-N,N-dimethylformimidamide

HRID 1713180

Reaktionsgleichung

Reaktionsgleichung von HRID 1713180
[NH2:1][C:2]1[N:7]([CH2:8][CH3:9])[C:6](=[O:10])[NH:5][C:4](=[O:11])[CH:3]=1.CO[CH:14](OC)[N:15]([CH3:17])[CH3:16]>CN(C)C(=O)C>[CH3:14][N:15]([CH3:17])[CH:16]=[N:1][C:2]1[N:7]([CH2:8][CH3:9])[C:6](=[O:10])[NH:5][C:4](=[O:11])[CH:3]=1

Komponenten

4

Edukt 2

HCID 78373Dimethylformamide dimethyl acetalHCID 8538996-Amino-1-ethyl-1,2,3,4-tetrahydropyrimidine-2,4-dione

Produkt 1

HCID 66630127N'-(3-Ethyl-2,6-dioxo-1,2,3,6-tetrahydropyrimidin-4-yl)-N,N-dimethylformimidamide

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 31374DimethylacetamideLösungsmittel

Reaktionsbedingungen

Temperatur
40 °C

Versuchsvorschrift

A suspension of 6-amino-1-ethyl-1,3-dihydropyrimidine-2,4-dione (0.77 g, 5 mmol) in anhydrous N,N-dimethylacetamide (25 ml) and N,N-dimethylformamide dimethylacetal (2.7 ml, 20 mmol) and was warmed at 40° C. for 90 minutes. Solvent was then removed under reduced pressure, and the residue triturated with ethanol, filtered, and washed with ethanol, to provide 6-[2-(dimethylamino)-1-azavinyl]-1-ethyl-1,3-dihydropyrimidine-2,4-dione, a compound of formula (6).

Aufarbeitung

  1. customSolvent was then removed under reduced pressure
  2. customthe residue triturated with ethanol
  3. filtrationfiltered
  4. washwashed with ethanol

Quellen und Nachweise

ORD-Eintrag
ord-f716dee1b2904028b4fe5852743a74d2
Quelldatensatz
uspto-grants-2010_09
Patentnummer
US07795268B2

Verknüpfte Notizen

Wird geladen…