Oxalyl chloride → HCID 11436518, Verbindung

HRID 1714078

Reaktionsgleichung

Reaktionsgleichung von HRID 1714078
[F:1][C:2]([F:15])([F:14])[C:3]([NH:5][CH:6]([CH2:10][CH2:11][CH2:12][CH3:13])C(O)=O)=[O:4].C(Cl)(=O)[C:17]([Cl:19])=[O:18]>ClCCl.CN(C)C=O>[F:15][C:2]([F:1])([F:14])[C:3]([NH:5][CH2:6][CH2:10][CH2:11][CH2:12][CH2:13][C:17]([Cl:19])=[O:18])=[O:4]

Komponenten

5

Edukt 2

HCID 65578Oxalyl chlorideHCID 3035902-[(2,2,2-Trifluoroacetyl)amino]hexanoic acid

Produkt 1

HCID 11436518HCID 11436518, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 6228DimethylformamideKatalysatorHCID 6344DichloromethaneLösungsmittel

Reaktionsbedingungen

Temperatur
0 °C

Versuchsvorschrift

735 mg(3 mmol) (2,2,2-trifluoro-acetylamino)-hexanoic acid were dissolved in 5 mL dried dichloromethane and stirred under argon flux at 0° C. Then, 0.6 mL (6.6 mmol) oxalyl chloride were added dropwise at 0° C., a few drops of dried dimethylformamide were also added dropwise which lead to gas development and yellow colouring of the previously white mixture. The mixture, was stirred at room temperature for 70 min. Then the mixture was repeatedly evaporated with dichloromethane. The crude product was used directly in the next step.

Aufarbeitung

  1. stirringThe mixture, was stirred at room temperature for 70 min
  2. customThen the mixture was repeatedly evaporated with dichloromethane

Quellen und Nachweise

ORD-Eintrag
ord-b39c693e046641f98956833f6e0466d1
Quelldatensatz
uspto-grants-2010_09
Patentnummer
US07795423B2

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