1-Ethyl-3-(3'-dimethylaminopropyl)carbodiimide → 1-[3-(3-Fluoro-phenylamino)-6,7-dimethoxy-4H-indeno[1,2-c]pyrazol-1-yl]-3-pyrrolidin-1-yl-propane-1,3-dione

HRID 1714446

Reaktionsgleichung

Reaktionsgleichung von HRID 1714446
[CH3:1][O:2][C:3]1[CH:4]=[C:5]2[C:20](=[CH:21][C:22]=1[O:23][CH3:24])[C:8]1[NH:9][N:10]=[C:11]([NH:12][C:13]3[CH:18]=[CH:17][CH:16]=[C:15]([F:19])[CH:14]=3)[C:7]=1[CH2:6]2.[O:25]=[C:26]([N:31]1[CH2:35][CH2:34][CH2:33][CH2:32]1)[CH2:27][C:28](O)=[O:29].CN(C)CCCN=C=NCC.O.OC1C2N=NNC=2C=CC=1.CCN(C(C)C)C(C)C>CN(C=O)C>[F:19][C:15]1[CH:14]=[C:13]([NH:12][C:11]2[C:7]3[CH2:6][C:5]4[C:20](=[CH:21][C:22]([O:23][CH3:24])=[C:3]([O:2][CH3:1])[CH:4]=4)[C:8]=3[N:9]([C:28](=[O:29])[CH2:27][C:26]([N:31]3[CH2:35][CH2:34][CH2:33][CH2:32]3)=[O:25])[N:10]=2)[CH:18]=[CH:17][CH:16]=1

Komponenten

7

Edukt 5

HCID 159081-Ethyl-3-(3'-dimethylaminopropyl)carbodiimideHCID 81531DiisopropylethylamineHCID 9797370Jnj-101984092×HCID 11457817HCID 11457817, Verbindung2×HCID 178526939HCID 178526939, Verbindung

Produkt 1

HCID 184454421-[3-(3-Fluoro-phenylamino)-6,7-dimethoxy-4H-indeno[1,2-c]pyrazol-1-yl]-3-pyrrolidin-1-yl-propane-1,3-dione

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6228DimethylformamideLösungsmittel

Versuchsvorschrift

A mixture of (6,7-Dimethoxy-1,4-dihydro-indeno[1,2-c]pyrazol-3-yl)-(3-fluoro-phenyl)-amine (Compound 14) (0.36, 1.0 mmol), 3-Oxo-3-pyrrolidin-1-yl-propionic acid (Compound 28a) (0.157 g, 1.0 mmole), 1-(3-Dimethylaminopropyl)-3-ethylcarbodiimide (EDC) (0.24 g, 1.25 mmol), hydroxybenzo-triazole hydrate (HOBT) (0.17 g, 1.25 mmol) and DIEA (0.220 mL, 1.25 mmol) was stirred in 10 mL DMF over night at room temperature. The reaction was quenched with saturated NaHCO3 and extracted with EtOAc. The solvent was removed in vacuo and the crude material was prepped on the Gilson. Lyophilization produced a white powder. MS m/z 465.1 (M+H)+;

Aufarbeitung

  1. customThe reaction was quenched with saturated NaHCO3
  2. extractionextracted with EtOAc
  3. customThe solvent was removed in vacuo
  4. customLyophilization produced a white powder

Quellen und Nachweise

ORD-Eintrag
ord-6d5a3b41da964a938e5e04ce479d600f
Quelldatensatz
uspto-grants-2010_09
Patentnummer
US07795440B2

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