1H-Indole-2-carboxylic acid, 1-methyl- → 1-Methyl-1H-indole-2-carbonyl chloride

A suspension of 1-methyl-1H-2-indolecarboxylic acid (0.485 g, 2.769 mmol) in dichloromethane (10 mL) at 0° C. was treated with oxalyl chloride (0.369 g, 2.91 mmol) and one drop of dimethyl formamide. The reaction mixture was stirred at 0° C. for 1 hour and at room temperature for 2 hours. The solvent was removed under reduced pressure and dried on the high vacuum for 1 hour. The residue was used directly in the subsequent reaction without further purification or analysis.

1. customThe solvent was removed under reduced pressure
2. customdried on the high vacuum for 1 hour
3. customThe residue was used directly in the subsequent reaction without further purification or analysis

ORD-Eintrag

ord-582438ec3357466097420a38f45a9681

Quelldatensatz

uspto-grants-2010_06

DOI

10.6084/m9.figshare.5104873.v1

Patentnummer

US07737160B2