Hydrochloric Acid → 4-Bromo-3-fluoro-4'-methoxybenzophenone

Temperatur

-5 °C

To a stirred solution of 4-bromo-3-fluorobenzoyl chloride (3.00 g, 12.6 mmol) and anisole (1.65 mL, 1.65 g, 15.2 mmol, 1.20 eq) in DCM (30 mL) at −5° C. was added, portion-wise, over 5 minutes, AlCl3 (2.54 g, 19.0 mmol, 1.50 eq) as a powder. The reaction was stirred at −5° C. for 2 h. The reaction was poured onto a mixture of 1 N HCl (100 mL) and ice (200 g) and stirred for 1 h. The DCM layer was washed with saturated aq. NaHCO3 (100 mL) and brine (100 mL) then dried (MgSO4) and concentrated. The resulting white solid was triturated with ˜100 mL hexanes, filtered and air-dried overnight to afford 3.26 g (83%) of compound 185. 1H NMR (400 MHz, DMSO-d6): δ 3.87 (s, 3H), 7.11 (d, J=8.9 Hz, 2H), 7.45 (d, J=8.9 Hz, 1H), 7.64 (d, J=8.9 Hz, 1H), 7.78 (d, J=8.9 Hz, 2H), 7.91 (t, J=7.1 Hz, 1H).

1. stirringstirred for 1 h
2. washThe DCM layer was washed with saturated aq. NaHCO3 (100 mL) and brine (100 mL)
3. dry with materialthen dried (MgSO4)
4. concentrationconcentrated
5. customThe resulting white solid was triturated with ˜100 mL hexanes
6. filtrationfiltered
7. customair-dried overnight

ORD-Eintrag

ord-f1da12d86b8c4e278c6c058cb13cec27

Quelldatensatz

uspto-grants-2010_09

DOI

10.6084/m9.figshare.5104873.v1

Patentnummer

US07799828B2