Hydrazine hydrate (1:1) → HCID 57664928, Verbindung
Reaktionsgleichung
[CH:1]1([NH:4][C:5]([C:7]2[N:8]=[N:9][N:10]([C:24]3[CH:29]=[CH:28][C:27]([C:30]([NH:32][CH2:33][CH3:34])=[O:31])=[CH:26][CH:25]=3)[C:11]=2[CH2:12][N:13]2C(=O)C3C(=CC=CC=3)C2=O)=[O:6])[CH2:3][CH2:2]1.O.NN>C(O)C>[NH2:13][CH2:12][C:11]1[N:10]([C:24]2[CH:25]=[CH:26][C:27]([C:30]([NH:32][CH2:33][CH3:34])=[O:31])=[CH:28][CH:29]=2)[N:9]=[N:8][C:7]=1[C:5]([NH:4][CH:1]1[CH2:3][CH2:2]1)=[O:6]Komponenten
4
Edukt 2
Produkt 1
Reagenzien, Katalysatoren, Lösungsmittel 1
Versuchsvorschrift
A solution of N-cyclopropyl-5-[(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)methyl]-1-{4-[(ethylamino)carbonyl]phenyl}-1H-1,2,3-triazole-4-carboxamide (0.9 g, 2.0 mmol) obtained in Example 1196 and hydrazine hydrate (200 mg, 4.0 mmol) in ethanol (20 ml) was boiled under reflux for 1 hr, and precipitated insoluble material was filtered off. The filtrate was concentrated to dryness to give the title compound as a white powder (0.65 g, 99%).