Sodium Azide → 4-Azidomethyl-2-fluorobenzonitrile

HRID 1717492Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1717492
CS(O[CH2:6][C:7]1[CH:12]=[CH:11][C:10]([C:13]#[N:14])=[C:9]([F:15])[CH:8]=1)(=O)=O.[N-:16]=[N+:17]=[N-:18].[Na+]>O>[N:16]([CH2:6][C:7]1[CH:12]=[CH:11][C:10]([C:13]#[N:14])=[C:9]([F:15])[CH:8]=1)=[N+:17]=[N-:18]

Komponenten

4

Edukt 2

HCID 33557Sodium AzideHCID 219046204-Cyano-3-fluorobenzyl methanesulfonate

Produkt 1

HCID 219046434-Azidomethyl-2-fluorobenzonitrile

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 962WaterLösungsmittel

Versuchsvorschrift

To an ice cooled solution of 4-cyano-3-fluorobenzyl methanesulfonate (1.8 g, 7.9 mmol; see step (iii) above) was added sodium azide (0.80 g, 0.012 mol). The mixture was stirred overnight and then poured into 200 mL of water and extracted three times with diethyl ether. The combined ethereal phase washed five times with water, dried (Na2SO4) and evaporated. The crude colourless oil could be used without further purification. Yield: 1.2 g (87%).

Aufarbeitung

  1. extractionextracted three times with diethyl ether
  2. washThe combined ethereal phase washed five times with water
  3. dry with materialdried (Na2SO4)
  4. customevaporated
  5. customThe crude colourless oil could be used without further purification

Quellen und Nachweise

ORD-Eintrag
ord-d91c0f3eeefe4e2db5924a5ebac5a6d2
Quelldatensatz
uspto-grants-2010_09
Patentnummer
US07803954B2

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