Hydrochloric Acid → 2-((Methylsulfonyl)oxy)propanoic acid

HRID 1719368Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1719368
[OH-].[K+].[CH3:3][S:4]([O:7][CH:8]([CH3:14])[C:9]([O:11]CC)=[O:10])(=[O:6])=[O:5].Cl>O>[CH3:3][S:4]([O:7][CH:8]([CH3:14])[C:9]([OH:11])=[O:10])(=[O:6])=[O:5]

Komponenten

5

Edukt 3

HCID 313Hydrochloric AcidHCID 14797Potassium HydroxideHCID 3509469Ethyl 2-methylsulfonyloxypropanoate

Produkt 1

HCID 127615472-((Methylsulfonyl)oxy)propanoic acidAusbeute 95,4 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 962WaterLösungsmittel

Versuchsvorschrift

5.02 G (89.5 mmol) of potassium hydroxide was dissolved in 50 ml of water and stirred at 10°-20° C. 14.46 G (73.70 mmol) of the ethyl (-)-2-methanesulfonyloxypropionate obtained in Example 1 was added to this, and the mixture was stirred at the same temperature for 5 hours. Concentrated hydrochloric acid was added to bring the pH below 1, and extraction was performed with ethyl acetate (30 ml, 3 times). Anhydrous sodium sulfate and anhydrous magnesium sulfate were added in sequence to dry the extract, which was then vacuum concentrated, and 11.83 g of (-)-2-methanesulfonyloxypropionic acid was obtained in the form of crystals of mp 65°-72° C. Yield 95.4%.

Aufarbeitung

  1. stirringwas stirred at the same temperature for 5 hours
  2. extractionthe pH below 1, and extraction
  3. additionAnhydrous sodium sulfate and anhydrous magnesium sulfate were added in sequence
  4. customto dry the extract, which
  5. concentrationvacuum concentrated

Quellen und Nachweise

ORD-Eintrag
ord-2a0a957ddad140f7bd79cb5b7554b0b6
Quelldatensatz
uspto-grants-1985_09
Patentnummer
US04539420

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