Butyl 3-(p-tert-butylphenoxy)-propionate → 3-p-t-Butyl-phenoxypropanol

Temperatur

-5 °C

This ester 21.0 g was dissolved in 500 ml dry ether and cooled to -5° C. in an ice/acetone bath. To the cold solution was added, cautiously, a slurry of 3.5 g lithium aluminum hydride in 100 ml dry ether. After one hour the excess lithium aluminum hydride was destroyed by the cautious addition of 200 ml ethyl acetate, then 50 ml water. The solution was filtered and the filtate partitioned between 200 ml ether - 200 ml water. The organic layer was removed, dried, and evaporated to a yellow oil which was vacuum distilled (116° C./0.35 mm) over potassium carbonate to a clear colorless oil, 3-p-t-butylphenoxypropanol, 10.1 g (64%).

1. additionTo the cold solution was added
2. customAfter one hour the excess lithium aluminum hydride was destroyed by the cautious addition of 200 ml ethyl acetate
3. filtrationThe solution was filtered
4. customthe filtate partitioned between 200 ml ether - 200 ml water
5. customThe organic layer was removed
6. customdried
7. customevaporated to a yellow oil which
8. distillationdistilled (116° C./0.35 mm) over potassium carbonate to a clear colorless oil, 3-p-t-butylphenoxypropanol, 10.1 g (64%)

ORD-Eintrag

ord-0faa6fc4dfc24edcbc14d310fbfea6e3

Quelldatensatz

uspto-grants-1985_09

DOI

10.6084/m9.figshare.5104873.v1

Patentnummer

US04543362