Formamide → 6-Nitroquinazolin-4-amine

HRID 1719914Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1719914
[NH2:1][C:2]1[CH:9]=[CH:8][C:7]([N+:10]([O-:12])=[O:11])=[CH:6][C:3]=1[C:4]#[N:5].C(=O)([O-])[O-].[K+].[K+].[CH:19]([NH2:21])=O.CN(C)C=O>O>[NH2:5][C:4]1[C:3]2[C:2](=[CH:9][CH:8]=[C:7]([N+:10]([O-:12])=[O:11])[CH:6]=2)[N:1]=[CH:19][N:21]=1

Komponenten

6

Edukt 4

HCID 713FormamideHCID 6228DimethylformamideHCID 11430Potassium CarbonateHCID 285322-Amino-5-nitrobenzonitrile

Produkt 1

HCID 130604546-Nitroquinazolin-4-amine

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 962WaterLösungsmittel

Reaktionsbedingungen

Temperatur
150 °C

Versuchsvorschrift

A mixture of 2-amino-5-nitrobenzonitrile (48.9 g), anhydrous potassium carbonate (45.6 g), formamide (240 ml) and N,N-dimethylformamide (200 ml) was stirred for 50 minutes at 150° C. and then cooled to ambient temperature. To the resultant mixture was added a small volume of water with stirring. Precipitated crystals were separated by filtration, washed three times with water and dried under reduced pressure to give crystalline 4-amino-6-nitroquinazoline (50.1 g).

Aufarbeitung

  1. temperaturecooled to ambient temperature
  2. stirringwith stirring
  3. customPrecipitated crystals
  4. customwere separated by filtration
  5. washwashed three times with water
  6. customdried under reduced pressure

Quellen und Nachweise

ORD-Eintrag
ord-1fb8b01d63f244b792d55d25c50d66f3
Quelldatensatz
uspto-grants-1985_09
Patentnummer
US04543356

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