[O:1]1[CH2:6][CH:2]1[CH:3]([OH:5])[CH3:4].Cl.[SH:8][CH2:9][CH2:10][C:11]([O:13][CH3:14])=[O:12]>C(Cl)Cl.C[O-].[Na+]>[CH3:14][O:13][C:11](=[O:12])[CH2:10][CH2:9][S:8][CH2:6][CH:2]([OH:1])[CH:3]([OH:5])[CH3:4]To a solution of 3,4-epoxy-2-butanol as obtained in Reference Example 43 (1.13 g) in methylene chloride (4 ml), methyl 3-mercaptopropionate (2.00 ml) and sodium methylate (260 μl) were added under ice cooling conditions, followed by stirring at room temperature for 1 day. To the reaction mixture, 1N hydrochloric acid was added, and the mixture was extracted with ethyl acetate; the solvent was distilled off under reduced pressure. The resulting residue was purified by silica gel column chromatography (ethyl acetate:hexane=2:1) to yield the title compound (1.47 g, yield 55%) as a colorless oily substance.
Wird geladen…
