N-Iodosuccinimide → 2-Ethoxycarbonylimino-3-(3-trifluoromethylphenyl)-5-iodothiazoline

HRID 1721043

Reaktionsgleichung

Reaktionsgleichung von HRID 1721043
[CH2:1]([O:3][C:4]([N:6]=[C:7]1[N:11]([C:12]2[CH:17]=[CH:16][CH:15]=[C:14]([C:18]([F:21])([F:20])[F:19])[CH:13]=2)[CH:10]=[CH:9][S:8]1)=[O:5])[CH3:2].[I:22]N1C(=O)CCC1=O>C(Cl)(Cl)Cl>[CH2:1]([O:3][C:4]([N:6]=[C:7]1[N:11]([C:12]2[CH:17]=[CH:16][CH:15]=[C:14]([C:18]([F:20])([F:21])[F:19])[CH:13]=2)[CH:10]=[C:9]([I:22])[S:8]1)=[O:5])[CH3:2]

Komponenten

4

Edukt 2

HCID 120273N-IodosuccinimideHCID 543520892-Ethoxycarbonylimino-3-(3-trifluoromethylphenyl)thiazoline

Produkt 1

HCID 539747642-Ethoxycarbonylimino-3-(3-trifluoromethylphenyl)-5-iodothiazolineAusbeute 14,3 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6212ChloroformLösungsmittel

Versuchsvorschrift

A solution of 2-ethoxycarbonylimino-3-(3-trifluoromethylphenyl) thiazoline (0.5 g) and N-iodosuccinimide (0.4 g) in chloroform (30 ml) was refluxed for 20 hours. After cooling, the reaction mixture was washed with an aqueous sodium sulfite solution and dried over anhydrous magnesium sulfate. The solvent was removed under reduced pressure, and the residue was subjected to column chromatography to give 0.1 g of 2-ethoxycarbonylimino-3-(3-trifluoromethylphenyl)-5-iodothiazoline (Compound No. 42).

Aufarbeitung

  1. temperatureAfter cooling
  2. washthe reaction mixture was washed with an aqueous sodium sulfite solution
  3. dry with materialdried over anhydrous magnesium sulfate
  4. customThe solvent was removed under reduced pressure

Quellen und Nachweise

ORD-Eintrag
ord-bcf119bf79d64353b3f077f58734c5f4
Quelldatensatz
uspto-grants-1996_04
Patentnummer
US05508415

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