1-Benzyl-3-acetamidopyrrolidine → 3-Acetamidopyrrolidine

HRID 1722085Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1722085
[C:1]([NH:4][CH:5]1[CH2:9][CH2:8][N:7](CC2C=CC=CC=2)[CH2:6]1)(=[O:3])[CH3:2]>C(O)C.O.[C].[Pd]>[C:1]([NH:4][CH:5]1[CH2:9][CH2:8][NH:7][CH2:6]1)(=[O:3])[CH3:2]

Komponenten

5

Edukt 1

HCID 41983391-Benzyl-3-acetamidopyrrolidine

Produkt 1

HCID 5227153-AcetamidopyrrolidineAusbeute 97,9 %

Reagenzien, Katalysatoren, Lösungsmittel 3

HCID 178418390HCID 178418390, VerbindungKatalysatorHCID 702EthanolLösungsmittelHCID 962WaterLösungsmittel

Versuchsvorschrift

To a solution of the above 3-acetylamino-1-benzylpyrrolidine (4.0 g) in ethanol (30 ml) was added 10% palladium-carbon (0.8 g) in water (1 ml). The mixture was shaken at room temperature for 22 hours under hydrogen pressure of 55 p.s.i. using Parr hydrogenator. The catalyst was filtered off and the solvent was distilled off under reduced pressure. The residue was dissolved in chloroform and dried over anhydrous magnesium sulfate, followed by distilling off the solvent to give 3-acetylaminopyrrolidine (2.3 g) as oil.

Aufarbeitung

  1. filtrationThe catalyst was filtered off
  2. distillationthe solvent was distilled off under reduced pressure
  3. dissolutionThe residue was dissolved in chloroform
  4. dry with materialdried over anhydrous magnesium sulfate
  5. distillationby distilling off the solvent

Quellen und Nachweise

ORD-Eintrag
ord-004e964c05094558bb944e448effad59
Quelldatensatz
uspto-grants-1989_08
Patentnummer
US04853469

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