Potassium Hydroxide → HCID 23049308, Verbindung

HRID 1722219Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1722219
[C:1]1([C:7]#[C:8][CH2:9][CH2:10]/[CH:11]=[CH:12]/[C:13]([O:15]CC)=[O:14])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[OH-].[K+]>CO.O>[C:1]1([C:7]#[C:8][CH2:9][CH2:10]/[CH:11]=[CH:12]/[C:13]([OH:15])=[O:14])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1

Komponenten

5

Edukt 2

HCID 14797Potassium HydroxideHCID 10656958HCID 10656958, Verbindung

Produkt 1

HCID 23049308HCID 23049308, VerbindungAusbeute 91,2 %

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 887MethanolLösungsmittelHCID 962WaterLösungsmittel2×

Reaktionsbedingungen

Temperatur
50 °C

Versuchsvorschrift

To a solution of ethyl 7-phenylhept-2E-en-6-ynoate (2.5 g) in methanol was added KOH (2.6 g) in water (6 ml). The mixture was stirred at 50° C. under a nitrogen atmosphere for 40 minutes, cooled, diluted with water (20 ml) and washed with ether (15 ml). The aqueous layer was acidified with 10% HCl and extracted with ether. The ether extracts were combined and dried over MgSO4, and the solvent was distilled off (adding dry benzene (4 ml) to form azeotrope with traces of water) to give 7-phenylhept-2E-en-6-ynoic acid (2 g) as a colourless oily solid.

Aufarbeitung

  1. temperaturecooled
  2. washwashed with ether (15 ml)
  3. extractionextracted with ether
  4. dry with materialdried over MgSO4
  5. distillationthe solvent was distilled off
  6. addition(adding dry benzene (4 ml) to form azeotrope with traces of water)

Quellen und Nachweise

ORD-Eintrag
ord-025e0a7adfa04361ba9862272893340c
Quelldatensatz
uspto-grants-1989_08
Patentnummer
US04855086

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