4-Methylmorpholine → HCID 57035141, Verbindung

Temperatur

0 °C

To (2-propylmercapto)acetic acid (44.3 mg, 0.33 mmol) in the THF (3 mL) at 0°(b) was added N-methylmorpholine (37 microliters, 0.34 mmol) followed by isobutylchloroformate (43 microliters, 0.33 mmol). The mixture was stirred at 0° C. for 15 minutes and (3S,4S)-1-amino-3-hydroxy-4-t-butyloxycarbonylamino-5-cyclohexylpentane (51.0 mg, 0.17 mmol) was added followed by stirring at 0° C. for 15 minutes and at 25° C. for 2 hours. The mixture was poured into ethyl acetate, washed with 0.5 M H3PO4, 2 M Na2SO4 and evaporated to afford 36 mg (50%) of the desired compound. Mass spectrum: (M+1)+ =417.

1. stirringby stirring at 0° C. for 15 minutes and at 25° C. for 2 hours
2. washwashed with 0.5 M H3PO4, 2 M Na2SO4
3. customevaporated

ORD-Eintrag

ord-13a984ef6b20457abac97b0ce9572ef8

Quelldatensatz

uspto-grants-1989_08

DOI

10.6084/m9.figshare.5104873.v1

Patentnummer

US04857507