HCID 178453697, Verbindung → Formate

HRID 1723268

Reaktionsgleichung

Reaktionsgleichung von HRID 1723268
C([O:5][C:6]([NH:8][CH2:9][CH2:10][NH:11][C:12]([C:14]1[N:18]([CH2:19][C:20]2[CH:25]=[C:24]([F:26])[CH:23]=[C:22]([F:27])[CH:21]=2)[C:17]([SH:28])=[N:16][CH:15]=1)=[O:13])=[O:7])(C)(C)C>C(O)=O>[NH2:8][CH2:9][CH2:10][NH:11][C:12]([C:14]1[N:18]([CH2:19][C:20]2[CH:25]=[C:24]([F:26])[CH:23]=[C:22]([F:27])[CH:21]=2)[C:17]([SH:28])=[N:16][CH:15]=1)=[O:13].[CH:6]([O-:7])=[O:5]

Komponenten

4

Edukt 1

HCID 178453697HCID 178453697, Verbindung

Produkt 2

HCID 283FormateHCID 178511365HCID 178511365, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 284Formic AcidLösungsmittel

Versuchsvorschrift

A solution of N-(t-butyloxycarbonylaminoethyl)-1-(3,5-diflurobenzyl)-2-mercaptoimidazole-5-carboxamide acid (1.29 g, 3.13 mmole) prepared as above in 98% formic acid (40 ml) was stirred under an argon atmosphere for 3 hours and the solvent was removed under vacuum. The resulting oil was triturated with ether, and the product was filtered and dried to give N-(2-aminoethyl)-1-(3,5-difluorobenzyl)-2-mercaptoimidazole-5-carboxamide, formate, m.p.: 195°-196° C. (0.630 g, 56%).

Aufarbeitung

  1. customthe solvent was removed under vacuum
  2. customThe resulting oil was triturated with ether
  3. filtrationthe product was filtered
  4. customdried

Quellen und Nachweise

ORD-Eintrag
ord-46116c0579c54270987eca5261a39935
Quelldatensatz
uspto-grants-1989_08
Patentnummer
US04859779

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