Sodium Hydroxide → HCID 11961759, Verbindung

HRID 1723427Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1723427
O.Br.Br.[CH3:4][N:5]([CH:15]1[CH2:20][CH2:19][NH:18][CH2:17][CH2:16]1)[C:6]1[S:7][C:8]2[CH:14]=[CH:13][CH:12]=[CH:11][C:9]=2[N:10]=1.[OH-].[Na+]>O>[CH3:4][N:5]([CH:15]1[CH2:20][CH2:19][NH:18][CH2:17][CH2:16]1)[C:6]1[S:7][C:8]2[CH:14]=[CH:13][CH:12]=[CH:11][C:9]=2[N:10]=1

Komponenten

4

Edukt 2

HCID 14798Sodium HydroxideHCID 20060646HCID 20060646, Verbindung

Produkt 1

HCID 11961759HCID 11961759, VerbindungAusbeute 100 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 962WaterLösungsmittel

Versuchsvorschrift

A solution of 427 parts of N-methyl-N-(4-piperidinyl)-2-benzothiazolamine dihydrobromide monohydrate in 1500 parts of water was treated with a sodium hydroxide solution 50%. The product was extracted twice with trichloromethane. The combined organic layers were washed with water, dried, filtered and evaporated. The residue was crystallized from 490 parts of 2,2'-oxybispropane. The product was filtered off and dried, yielding 248 parts (100%) of N-methyl-N-(4-piperidinyl)-2-benzothiazolamine; mp. 86.9° C. (68).

Aufarbeitung

  1. extractionThe product was extracted twice with trichloromethane
  2. washThe combined organic layers were washed with water
  3. customdried
  4. filtrationfiltered
  5. customevaporated
  6. customThe residue was crystallized from 490 parts of 2,2'-oxybispropane
  7. filtrationThe product was filtered off
  8. customdried

Quellen und Nachweise

ORD-Eintrag
ord-5fce08df276244678f96d9cf352e81bf
Quelldatensatz
uspto-grants-1989_08
Patentnummer
US04861785

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