HCID 9851847, Verbindung → (-)-(3S,4R)-4-(4-fluoro-phenyl)-1-methyl-piperidine-3-carboxylic acid methyl ester
Reaktionsgleichung
[F:1][C:2]1[CH:7]=[CH:6][C:5]([C@H:8]2[CH2:13][CH2:12][N:11]([CH3:14])[CH2:10][C@H:9]2[C:15]([O:17][CH3:18])=[O:16])=[CH:4][CH:3]=1.C[O-].[Na+]>C1(C)C=CC=CC=1>[F:1][C:2]1[CH:7]=[CH:6][C:5]([C@@H:8]2[CH2:13][CH2:12][N:11]([CH3:14])[CH2:10][C@H:9]2[C:15]([O:17][CH3:18])=[O:16])=[CH:4][CH:3]=1Komponenten
4
Edukt 2
Produkt 1
Reagenzien, Katalysatoren, Lösungsmittel 1
Versuchsvorschrift
(±)-cis-4-(4'-Fluorophenyl)-3-methoxycarbonyl-1-methylpiperidine (2.0 g), prepared as in Example 2(a), in dry toluene was added to sodium methoxide in toluene and refluxed for 7 hours. After cooling to 0° and filtration, evaporation gave the title compound as an oil (1.97 g, 99%), purity 85-90%.