Hydrochloric Acid → Hydrochloric Acid

HRID 1723625Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1723625
[CH3:1][N:2]([CH3:14])[CH:3]1[CH2:8][CH2:7][CH:6]([NH:9][C:10]([NH:12][CH3:13])=[S:11])[CH2:5][CH2:4]1.[CH3:15]I.O.[ClH:18]>CO.[Cl-]>[CH3:1][N:2]([CH3:14])[C@H:3]1[CH2:4][CH2:5][C@H:6]([NH:9][C:10](=[N:12][CH3:13])[S:11][CH3:15])[CH2:7][CH2:8]1.[ClH:18]

Komponenten

8

Edukt 4

HCID 313Hydrochloric AcidHCID 962WaterHCID 6328Methyl iodideHCID 42216371-(4-Dimethylaminocyclohexyl)-3-methyl-thiourea

Produkt 2

HCID 313Hydrochloric AcidHCID 178485022HCID 178485022, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 312ChlorideLösungsmittelHCID 887MethanolLösungsmittel

Versuchsvorschrift

A mixture of 0.50 g of 1-(4-dimethylaminocyclohexyl)-3-methyl-thiourea in 10 ml of MeOH, 1.16 ml of 2M HCl (in MeOH) and 0.36 g of methyliodide is stirred at RT. From the mixture obtained solvent is evaporated and the evaporation residue obtained is treated with H2O. 10 ml of a strong basic ion exchanger in chloride form (Amberlite IRA 400 (Cl)R) are added to the aqueous mixture obtained and the mixture obtained is stirred at RT. A precipitate obtained is filtrated off and the filtrate obtained is lyophilized. 1-(trans-4-Dimethylamino-cyclohexyl)-2,3-dimethyl-isothiourea in the form of a hydrochloride is obtained.

Aufarbeitung

  1. customFrom the mixture obtained solvent
  2. customis evaporated
  3. customthe evaporation residue obtained
  4. customobtained
  5. customthe mixture obtained
  6. stirringis stirred at RT
  7. customA precipitate obtained
  8. filtrationis filtrated off
  9. customthe filtrate obtained

Quellen und Nachweise

ORD-Eintrag
ord-6865711830564f9ba16c6da1dc7ac535
Quelldatensatz
uspto-grants-2009_02
Patentnummer
US07485632B2

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