Triethylamine → HCID 23631899, Verbindung

A mixture of (5-Bromo-pyridin-2-yl)-methanol (60 mg, 0.32 mmol) in dichloromethane (2 ml) was cooled in as ice bath. To the mixture was then added triethylamine (0.13 mL, 0.96 mmol) followed by methanesulfonyl chloride (0.05 mL, 0.64 mmol). The reaction mixture was stirred at room temperature for 2 hours. To the reaction mixture was added saturated aqueous sodium bicarbonate (5 mL). The organic phase was separated and the aqueous phase extracted further with dichloromethane (2×5 mL). The combined organic phase was washed with brine, dried over sodium sulfate and concentrated to give the product as a pale brown oil.

1. temperaturewas cooled in as ice bath
2. customThe organic phase was separated
3. extractionthe aqueous phase extracted further with dichloromethane (2×5 mL)
4. washThe combined organic phase was washed with brine
5. dry with materialdried over sodium sulfate
6. concentrationconcentrated

ORD-Eintrag

ord-4a3e0bbcdc4746bfb6b15171314d9ff7

Quelldatensatz

uspto-grants-2009_02

DOI

10.6084/m9.figshare.5104873.v1

Patentnummer

US07485722B2