Diisopropylethylamine → (4-{4-[3-Methyl-4-(6-methyl-pyridin-3-yloxy)-phenylamino]quinazolin-6-yl}-thiazol-2-ylmethyl)-carbamic acid ter-butyl ester

HRID 1725137Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1725137
[C:1]([O:5][C:6](=[O:18])[NH:7][CH2:8][C:9]1[S:10][CH:11]=[C:12]([Sn](C)(C)C)[N:13]=1)([CH3:4])([CH3:3])[CH3:2].Cl.I[C:21]1[CH:22]=[C:23]2[C:28](=[CH:29][CH:30]=1)[N:27]=[CH:26][N:25]=[C:24]2[NH:31][C:32]1[CH:37]=[CH:36][C:35]([O:38][C:39]2[CH:40]=[N:41][C:42]([CH3:45])=[CH:43][CH:44]=2)=[C:34]([CH3:46])[CH:33]=1.CCN(C(C)C)C(C)C.CCOC(C)=O.CO>CN(C=O)C.Cl[Pd](Cl)([P](C1C=CC=CC=1)(C1C=CC=CC=1)C1C=CC=CC=1)[P](C1C=CC=CC=1)(C1C=CC=CC=1)C1C=CC=CC=1>[C:1]([O:5][C:6](=[O:18])[NH:7][CH2:8][C:9]1[S:10][CH:11]=[C:12]([C:21]2[CH:22]=[C:23]3[C:28](=[CH:29][CH:30]=2)[N:27]=[CH:26][N:25]=[C:24]3[NH:31][C:32]2[CH:37]=[CH:36][C:35]([O:38][C:39]3[CH:40]=[N:41][C:42]([CH3:45])=[CH:43][CH:44]=3)=[C:34]([CH3:46])[CH:33]=2)[N:13]=1)([CH3:4])([CH3:3])[CH3:2]

Komponenten

7

Edukt 4

HCID 81531DiisopropylethylamineHCID 21584119Ethylacetate methanolHCID 666233074-Quinazolinamine,6-iodo-n-[3-methyl-4-[(6-methyl-3-pyridinyl)oxy]phenyl]-,hydrochlorideHCID 66623970(4-Trimethylstannyl-thiazol-2-ylmethyl)-carbamic acid tert-butyl ester

Produkt 1

HCID 131727277(4-{4-[3-Methyl-4-(6-methyl-pyridin-3-yloxy)-phenylamino]quinazolin-6-yl}-thiazol-2-ylmethyl)-carbamic acid ter-butyl esterAusbeute 29,3 %

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 178418476HCID 178418476, VerbindungKatalysatorHCID 6228DimethylformamideLösungsmittel

Reaktionsbedingungen

Temperatur
100 °C

Versuchsvorschrift

(4-Trimethylstannyl- thiazol-2-ylmethyl)-carbamic acid tert-butyl ester (191 mg, 0.507 mmol) and [3-Methyl-4-(6-methyl-pyridin-3-yloxy)-phenyl]-(6-iodo-quinazolin-4-yl)-amine hydrochloride (0.251 g, 0.478 mmol) (from Step C, Example 3) are dissolved in anhydrous DMF under a nitrogen atmosphere. Hunig's base (0.44 ml, 2.53 mmol), and PdCl2(PPh3)2 are added to the reaction mixture at room temperature. The reaction mixture is degassed and heated at 100° C. overnight. After cooling to room temperature the reaction mixture is diluted with with water and thoroughly extracted with EtOAc and DCM. The combined organic extracts are dried (Na2SO4) and concentrated under reduced pressure. Flash chromatography on silica with EtOAc-MeOH as an eluant affords 81 mg (0.14 mmol, 28%) of clean desired product.

Aufarbeitung

  1. customThe reaction mixture is degassed
  2. temperatureAfter cooling to room temperature the reaction mixture
  3. additionis diluted with with water
  4. extractionthoroughly extracted with EtOAc and DCM
  5. dry with materialThe combined organic extracts are dried (Na2SO4)
  6. concentrationconcentrated under reduced pressure

Quellen und Nachweise

ORD-Eintrag
ord-432725857a0f4b3cb871a5f2fc48c8ec
Quelldatensatz
uspto-grants-2009_02
Patentnummer
US07488823B2

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