Water → Methyl 5-nitroquinoline-8-carboxylate

HRID 1725518

Reaktionsgleichung

Reaktionsgleichung von HRID 1725518
[N+:1]([C:4]1[CH:13]=[CH:12][C:11]([C:14]([OH:16])=[O:15])=[C:10]2[C:5]=1[CH:6]=[CH:7][CH:8]=[N:9]2)([O-:3])=[O:2].IC.[C:19](=O)([O-])[O-].[K+].[K+].O>CN(C=O)C>[CH3:19][O:15][C:14]([C:11]1[CH:12]=[CH:13][C:4]([N+:1]([O-:3])=[O:2])=[C:5]2[C:10]=1[N:9]=[CH:8][CH:7]=[CH:6]2)=[O:16]

Komponenten

6

Edukt 4

HCID 962WaterHCID 6328Methyl iodideHCID 11430Potassium CarbonateHCID 154053315-Nitroquinoline-8-carboxylic acid

Produkt 1

HCID 68521805Methyl 5-nitroquinoline-8-carboxylateAusbeute 78,4 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6228DimethylformamideLösungsmittel

Versuchsvorschrift

To a stirred solution of 300 mg (1.375 mmol) of 5-nitroquinoline-8-carboxilic acid (Breckenridge, J. G. Et al., Canadian J. of Research Sect. B; 1947, 25, 49) in DMF (6 mL), 546 mg (3.850 mmol) of iodomethane and 190 mg (1.375 mmol) of potassium carbonate were added. The resulting mixture was stirred at room temperature for one hour. Water (10 mL) was added and the product collected by filtration. The residue was washed with water and dried to yield the title compound (250 mg, 78.4%).

Aufarbeitung

  1. filtrationthe product collected by filtration
  2. washThe residue was washed with water
  3. customdried

Quellen und Nachweise

ORD-Eintrag
ord-5ee214cf2dbe45b78e8225f89264efb3
Quelldatensatz
uspto-grants-2009_02
Patentnummer
US07491722B2

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