Benzyl 4-(3-oxo-2,3-dihydropyridazin-4-yl)piperidine-1-carboxylate → HCID 57562526, Verbindung
Reaktionsgleichung
[O:1]=[C:2]1[C:7]([CH:8]2[CH2:13][CH2:12][N:11](C(OCC3C=CC=CC=3)=O)[CH2:10][CH2:9]2)=[CH:6][CH:5]=[N:4][NH:3]1>CCO.[Pd]>[NH:11]1[CH2:10][CH2:9][CH:8]([C:7]2[C:2](=[O:1])[NH:3][N:4]=[CH:5][CH:6]=2)[CH2:13][CH2:12]1Komponenten
4
Edukt 1
Produkt 1
Reagenzien, Katalysatoren, Lösungsmittel 2
Versuchsvorschrift
A solution of benzyl 4-(3-oxo-2,3-dihydropyridazin-4-yl)piperidine-1-carboxylate (0.90 mg, 2.88 mmol) and 10% Pd/C (500 mg) in EtOH (25 mL), was hydrogenated under a balloon for 4 h. The reaction was filtered through Celite with more EtOH and concentrated to afford the title compound (465 mg). MS 180.1 (M+1).
Aufarbeitung
- filtrationThe reaction was filtered through Celite with more EtOH
- concentrationconcentrated
Quellen und Nachweise
- ORD-Eintrag
- ord-4df944db378c491da2ae95f90b12ee4c
- Quelldatensatz
- uspto-grants-2009_02
- Patentnummer
- US07491713B2
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