2-Methyl-2-(4-nitrophenoxy)propanamide → 2-(4-Aminophenoxy)-2-methylpropanamide

HRID 1725680Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1725680
[N+:1]([C:4]1[CH:16]=[CH:15][C:7]([O:8][C:9]([CH3:14])([CH3:13])[C:10]([NH2:12])=[O:11])=[CH:6][CH:5]=1)([O-])=O>CO.[Pd]>[NH2:1][C:4]1[CH:5]=[CH:6][C:7]([O:8][C:9]([CH3:14])([CH3:13])[C:10]([NH2:12])=[O:11])=[CH:15][CH:16]=1

Komponenten

4

Edukt 1

HCID 123215222-Methyl-2-(4-nitrophenoxy)propanamide

Produkt 1

HCID 575629072-(4-Aminophenoxy)-2-methylpropanamide

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 23938PalladiumKatalysatorHCID 887MethanolLösungsmittel

Versuchsvorschrift

2-(4-Nitrophenoxy)-2-methylpropanamide (51) was dissolved in methanol (50 mL) and to the solution was added 10% Pd—C (500 mg). The reaction mixture was reacted under hydrogen atmosphere (40 psi) for 1 hour. The catalyst was then filtered off over Celite. The filtrate was evaporated under reduced pressure to give 2-(4-aminophenoxy)-2-methylpropanamide as a white solid (52).

Aufarbeitung

  1. customThe reaction mixture was reacted under hydrogen atmosphere (40 psi) for 1 hour
  2. filtrationThe catalyst was then filtered off over Celite
  3. customThe filtrate was evaporated under reduced pressure

Quellen und Nachweise

ORD-Eintrag
ord-dc130dc860d14fd8bbe868a2e835c7c9
Quelldatensatz
uspto-grants-2009_02
Patentnummer
US07491732B2

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