Sodium Hydroxide → HCID 68869750, Verbindung

To a dry reaction flask equipped with a reflux condenser, a magnetic stirring bar and a rubber septum with a N2 inlet was placed 7-nitrobenz[1,4]oxazine (1.0 g, 5.55 mmol), tertabutyl ammonium chloride (56 mg), powdered NaOH (0.58 g) in dry DMF (10 mL). The reaction mixture was stirred at room temperature for 30 minutes. 3-(Bromomethyl)-pyridine hydrobromide (1.40 g, 5.55 mmol) was added. The reaction mixture was heated at 80° C. for over night, cooled to room temperature, poured in water (200 mL), left aside for 2 h, added ethyl acetate (200 mL). The organic layer was washed with water (2×200 mL), brine (200 mL), dried (Na2SO4) and concentrated. The solid was purified by silica gel column, eluted with EtOAc to give 0.67 g (44%) of the desired 7-nitro-4-(3-pyridylmethyl)benz[1,4]oxazine. 1H NMR (CDCl3, 300 MHz): δ 8.56 (d, 1H, J=4.8 Hz), 8.53 (s, 1H), 7.72 (m, 2H), 7.53 (m, 1H), 7.28 (dd, 1H, J=5.1 and 7.8 Hz), 6.57 (d, 1H, J=9.0 Hz), 4.61 (s, 2H), 4.29 (t, 2H, J=4.2 Hz), 3.59 (t, 2H, J=4.5 Hz); LCMS (m/z): 272 (MH+).

1. customTo a dry reaction flask
2. customequipped with a reflux condenser, a magnetic stirring bar
3. customa rubber septum with a N2 inlet was placed
4. temperatureThe reaction mixture was heated at 80° C. for over night
5. temperaturecooled to room temperature
6. waitleft aside for 2 h
7. washThe organic layer was washed with water (2×200 mL), brine (200 mL)
8. dry with materialdried (Na2SO4)
9. concentrationconcentrated
10. customThe solid was purified by silica gel column
11. washeluted with EtOAc

ORD-Eintrag

ord-7f0c91bd68bc4ec3b8298d702e4394bc

Quelldatensatz

uspto-grants-2009_02

DOI

10.6084/m9.figshare.5104873.v1

Patentnummer

US07491732B2