Water → (2r)-3-Aza-2-phenyl-4-(3,5-dimethylphenyl)but-3-en-1-ol

HRID 1726325

Reaktionsgleichung

Reaktionsgleichung von HRID 1726325
[CH3:1][C:2]1[CH:3]=[C:4]([CH:7]=[C:8]([CH3:10])[CH:9]=1)[CH:5]=O.C1C=CC([CH:17]([NH2:20])CO)=CC=1.[OH2:21].[C:22]1([CH3:28])[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=1>>[C:27]1([C@@H:22]([CH:28]=[CH:5][C:4]2[CH:3]=[C:2]([CH3:1])[CH:9]=[C:8]([CH3:10])[CH:7]=2)[CH2:23][OH:21])[CH:26]=[CH:25][CH:24]=[N:20][CH:17]=1

Komponenten

5

Edukt 4

HCID 962WaterHCID 1140TolueneHCID 34225Benzaldehyde, 3,5-dimethyl-HCID 924662-Amino-2-phenylethanol

Produkt 1

HCID 68464252(2r)-3-Aza-2-phenyl-4-(3,5-dimethylphenyl)but-3-en-1-ol

Versuchsvorschrift

A solution of 3,5-dimethylbenzaldehyde (30.0 g) and (R)-phenylglycinol (30.7 g) in toluene (200 ml) was refluxed for 3 hours with removing water. The reaction solution was concentrated to give the title compound (59.7 g) having the following physical data.

Aufarbeitung

  1. concentrationThe reaction solution was concentrated

Quellen und Nachweise

ORD-Eintrag
ord-e7f2b641c56243259bebfb11b0aea8ae
Quelldatensatz
uspto-grants-2009_02
Patentnummer
US07491748B2

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