(4-Benzyloxy-naphthalen-1-yloxy)-acetic Acid Ethyl Ester → (4-Hydroxy-naphthalen-1-yloxy)-acetic acid ethyl ester

HRID 1727002Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1727002
[CH2:1]([O:3][C:4](=[O:25])[CH2:5][O:6][C:7]1[C:16]2[C:11](=[CH:12][CH:13]=[CH:14][CH:15]=2)[C:10]([O:17]CC2C=CC=CC=2)=[CH:9][CH:8]=1)[CH3:2]>O1CCCC1.[Pd]>[CH2:1]([O:3][C:4](=[O:25])[CH2:5][O:6][C:7]1[C:16]2[C:11](=[CH:12][CH:13]=[CH:14][CH:15]=2)[C:10]([OH:17])=[CH:9][CH:8]=1)[CH3:2]

Komponenten

4

Edukt 1

HCID 69035941(4-Benzyloxy-naphthalen-1-yloxy)-acetic Acid Ethyl Ester

Produkt 1

HCID 69037588(4-Hydroxy-naphthalen-1-yloxy)-acetic acid ethyl esterAusbeute 73,6 %

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 23938PalladiumKatalysatorHCID 8028TetrahydrofuranLösungsmittel

Versuchsvorschrift

2.23 g (6.62 mmol) of (4-benzyloxy-naphthalen-1-yloxy)-acetic acid ethyl ester was dissolved in 20 ml of tetrahydrofuran and hydrogenated over 0.5 g of 10% of palladium on charcoal as catalyst at ambient temperature and atmospheric pressure. Filtering off the catalyst and evaporating the solvent yielded 1.2 g of the title compound as light brown solid.

Aufarbeitung

  1. filtrationFiltering off the catalyst
  2. customevaporating the solvent

Quellen und Nachweise

ORD-Eintrag
ord-c012bd1cc1394387a1f392d36b6dc0eb
Quelldatensatz
uspto-grants-2009_02
Patentnummer
US07495001B2

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