Sodium Hydroxide → Ropivacaine

HRID 1727380Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1727380
[CH3:1][CH2:2][CH2:3][N:4]1[C@H:9]([C:10]([NH:12][C:13]2[C:14]([CH3:20])=[CH:15][CH:16]=[CH:17][C:18]=2[CH3:19])=[O:11])[CH2:8][CH2:7][CH2:6][CH2:5]1.C(C(C(C([O-])=O)O)O)([O-])=O.[OH-].[Na+]>O>[CH3:1][CH2:2][CH2:3][N:4]1[C@H:9]([C:10]([NH:12][C:13]2[C:18]([CH3:19])=[CH:17][CH:16]=[CH:15][C:14]=2[CH3:20])=[O:11])[CH2:8][CH2:7][CH2:6][CH2:5]1

Komponenten

4

Edukt 2

HCID 14798Sodium HydroxideHCID 86594745Ropivacaine tartrate

Produkt 1

HCID 175805Ropivacaine

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 962WaterLösungsmittel

Versuchsvorschrift

Under stirring, 126 g of ropivacaine tartrate were dissolved in 200 ml of water. To the resulting solution was added a solution of sodium hydroxide 1N, adjusting the pH of the solution around 10. During the addition of the alkaline solution, occurs the precipitation of raw base ropivacaine. The solid is filtered, washed in about 100 ml of distilled water and taken to the stove for drying. MP=142°-145° C., m=70 g (η=85.9%), [α]D25=−74.6° (c=2, MeOH).

Aufarbeitung

  1. additionDuring the addition of the alkaline solution
  2. customthe precipitation of raw base ropivacaine
  3. filtrationThe solid is filtered
  4. washwashed in about 100 ml of distilled water
  5. customfor drying

Quellen und Nachweise

ORD-Eintrag
ord-e83da9cca65c475bb40009238be5a5fe
Quelldatensatz
uspto-grants-2009_02
Patentnummer
US07495105B2

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