N-Phenylglycine ethyl ester → ethyl 2-(N-phenylformamido)acetate

HRID 1728952

Reaktionsgleichung

Reaktionsgleichung von HRID 1728952
[CH2:1]([O:3][C:4](=[O:13])[CH2:5][NH:6][C:7]1[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=1)[CH3:2].[CH:14](OC(=O)C)=[O:15]>O>[CH2:1]([O:3][C:4](=[O:13])[CH2:5][N:6]([C:7]1[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=1)[CH:14]=[O:15])[CH3:2]

Komponenten

4

Edukt 2

HCID 75190N-Phenylglycine ethyl esterHCID 75269Acetic-formic anhydride

Produkt 1

HCID 14416604ethyl 2-(N-phenylformamido)acetateAusbeute 70 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 962WaterLösungsmittel

Versuchsvorschrift

N-Phenylglycine ethyl ester (100 g; 0-56 mol) was added in small portions to acetic formic anhydride (100 g; 1.14 mol) with vigorous stirring. The mixture was allowed to stir overnight, then it was poured into water, and extracted with ether. The ether solution was washed with sodium bicarbonate solution and then with water. The ether was evaporated in vacuo to give an oil which was distilled to give N-phenyl-N-formylglycine ethyl ester (81 g; 70%) having a bp 115°-117° C.

Aufarbeitung

  1. extractionextracted with ether
  2. washThe ether solution was washed with sodium bicarbonate solution
  3. customThe ether was evaporated in vacuo
  4. customto give an oil which
  5. distillationwas distilled

Quellen und Nachweise

ORD-Eintrag
ord-ab70f6dde5414ecabec30cbd5dd807d6
Quelldatensatz
uspto-grants-1994_07
Patentnummer
US05329012

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