Bromine → 4-(2',4'-Dichlorophenyl)-5-methylthiazole hydrobromide

HRID 1729272Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1729272
[Cl:1][C:2]1[CH:7]=[C:6]([Cl:8])[CH:5]=[CH:4][C:3]=1[C:9](=O)[CH2:10][CH3:11].[Br:13]Br.[CH:15]([NH2:17])=[S:16]>C(Cl)Cl>[BrH:13].[Cl:1][C:2]1[CH:7]=[C:6]([Cl:8])[CH:5]=[CH:4][C:3]=1[C:9]1[N:17]=[CH:15][S:16][C:10]=1[CH3:11]

Komponenten

5

Edukt 3

HCID 24408BromineHCID 1234672',4'-DichloropropiophenoneHCID 3005587Methanethioamide

Produkt 1

HCID 190124704-(2',4'-Dichlorophenyl)-5-methylthiazole hydrobromideAusbeute 53 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6344DichloromethaneLösungsmittel2×

Reaktionsbedingungen

Temperatur
20 °C

Versuchsvorschrift

To 2',4'-dichloropropiophenone (2.03 g; 0.01 mole) in methylene chloride (20 ml) was added excess bromine in methylene chloride (10 ml) dropwise at 20° C. The methylene chloride layer was washed with sodium sulphite solution and water, separated, dried (MgSO4) and evaporated. The residue was dissolved in ethanol (20 ml) and thioformamide (0.61 g; 0.01 mole) was added and the mixture stirred at 20° C. for 16 hours to give 4-(2',4'-dichlorophenyl)-5-methylthiazole hydrobromide (1.72 g; 53%).

Aufarbeitung

  1. washThe methylene chloride layer was washed with sodium sulphite solution and water
  2. customseparated
  3. dry with materialdried (MgSO4)
  4. customevaporated
  5. dissolutionThe residue was dissolved in ethanol (20 ml)

Quellen und Nachweise

ORD-Eintrag
ord-710cdbd9ed75436bbc898ae53e73aa5c
Quelldatensatz
uspto-grants-1994_07
Patentnummer
US05332753

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