Sodium Hydroxide → 7-[Cyano(4-hydroxynonyl)amino]-2-methylheptanoic acid

HRID 1729917Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1729917
C([O:4][CH:5]([CH2:24][CH2:25][CH2:26][CH2:27][CH3:28])[CH2:6][CH2:7][CH2:8][N:9]([CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][CH:17]([CH3:23])[C:18]([O:20]CC)=[O:19])[C:10]#[N:11])(=O)C.[OH-].[Na+]>C(O)C.O>[OH:4][CH:5]([CH2:24][CH2:25][CH2:26][CH2:27][CH3:28])[CH2:6][CH2:7][CH2:8][N:9]([CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][CH:17]([CH3:23])[C:18]([OH:20])=[O:19])[C:10]#[N:11]

Komponenten

5

Edukt 2

HCID 14798Sodium HydroxideHCID 86734144HCID 86734144, Verbindung

Produkt 1

HCID 714447117-[Cyano(4-hydroxynonyl)amino]-2-methylheptanoic acid

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 702EthanolLösungsmittelHCID 962WaterLösungsmittel

Versuchsvorschrift

To a solution of ethyl 7-[N-(4-acetoxynonyl)cyanamido] -2-methylheptanoate (7.6 g., 0.02 mole) in ethanol (50 ml.) is added a solution of sodium hydroxide (1.6 g., 0.04 mole) in water (15 ml.) and the reaction is stirred at ambient temperature for 20 hours. Then most of the ethanol is removed in vacuo and the residue taken up in water (150 ml.). The solution is extracted once with ether then acidified with hydrochloric acid (dil.). The oil that separates is extracted into ether, the ether is washed with brine, dried over sodium sulfate, then removed under vacuum to give 7-[N-(4-hydroxynonyl)cyanamido]-2-methylheptanoic acid as a yellow oil.

Aufarbeitung

  1. customThen most of the ethanol is removed in vacuo
  2. extractionThe solution is extracted once with ether
  3. extractionThe oil that separates is extracted into ether
  4. washthe ether is washed with brine
  5. dry with materialdried over sodium sulfate
  6. customremoved under vacuum

Quellen und Nachweise

ORD-Eintrag
ord-74acb03a106e417b970cefe90ee5e55b
Quelldatensatz
uspto-grants-1976_11
Patentnummer
US03989749

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