Isopropanol → HCID 21498784, Verbindung

HRID 1729989Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1729989
C([N:9]1[CH2:18][C:17]2[C:16](=[O:19])[NH:15][C:14]3[CH:20]=[CH:21][CH:22]=[CH:23][C:13]=3[C:12]=2[CH2:11][CH2:10]1)(=O)C1C=CC=CC=1.CC(O)C>O.OS(O)(=O)=O>[CH2:11]1[CH2:10][NH:9][CH2:18][C:17]2[C:16](=[O:19])[NH:15][C:14]3[CH:20]=[CH:21][CH:22]=[CH:23][C:13]=3[C:12]1=2

Komponenten

5

Edukt 2

HCID 3776IsopropanolHCID 214987793-Benzoyl-2,3,4,6-tetrahydrobenzo[c][2,7]naphthyridin-5(1H)-one

Produkt 1

HCID 21498784HCID 21498784, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 962WaterLösungsmittelHCID 1118Sulfuric AcidLösungsmittel2×

Versuchsvorschrift

A solution of 7.7 g (0.025 m) of 3-benzoyl-1,2,3,4-tetrahydrobenzo[c][2,7]naphthyridin-5(6H)-one in 30 ml of water, 10 ml of H2SO4, and 200 ml of 2-propanol was refluxed for 20 hr. After cooling, the solid was filtered and recrystallized from water, mp 292°-295° C. By analysis, this material contains 0.7 mole of H2SO4 per mole of base and was used as is for alkylation.

Aufarbeitung

  1. temperatureAfter cooling
  2. filtrationthe solid was filtered
  3. customrecrystallized from water, mp 292°-295° C

Quellen und Nachweise

ORD-Eintrag
ord-a5f8355d9316499f8b0646878de3c3ca
Quelldatensatz
uspto-grants-1976_11
Patentnummer
US03991064

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