Sodium Hydroxide → Ethnor

HRID 1730047

Reaktionsgleichung

Reaktionsgleichung von HRID 1730047
S(O)(O)(=O)=O.[C:6]1([CH:12]([N:14]2[C:18]([C:19]([O:21][CH2:22][CH3:23])=[O:20])=[CH:17][N:16]=[CH:15]2)[CH3:13])[CH:11]=[CH:10][CH:9]=[CH:8][CH:7]=1.[OH-].[Na+]>O>[C:6]1([CH:12]([N:14]2[C:18]([C:19]([O:21][CH2:22][CH3:23])=[O:20])=[CH:17][N:16]=[CH:15]2)[CH3:13])[CH:11]=[CH:10][CH:9]=[CH:8][CH:7]=1

Komponenten

4

Edukt 2

HCID 14798Sodium HydroxideHCID 3084993Ethyl 1-(1-phenylethyl)-1H-imidazole-5-carboxylate sulfate

Produkt 1

HCID 36339Ethnor

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 962WaterLösungsmittel

Versuchsvorschrift

A solution of 47.5 parts of (-)-ethyl 1-(1-phenylethyl)-1H-imidazole-5-carboxylate sulfate in 500 parts of water is alkalized with 14 parts of a sodium hydroxide solution 50%. The product is extracted twice with 325 parts of dichloromethane. The combined extracts are dried, filtered and evaporated in vacuo. The residue is crystallized from 2,2'-oxybispropane, yielding (-)-ethyl 1-(1-phenylethyl)-1H-imidazole-5-carboxylate.

Aufarbeitung

  1. extractionThe product is extracted twice with 325 parts of dichloromethane
  2. customThe combined extracts are dried
  3. filtrationfiltered
  4. customevaporated in vacuo
  5. customThe residue is crystallized from 2,2'-oxybispropane

Quellen und Nachweise

ORD-Eintrag
ord-5bdca24f7ac64c88b979240b23bff893
Quelldatensatz
uspto-grants-1976_11
Patentnummer
US03991072

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