1-(Thiazol-2-yl)piperazine → 2-{2-[4-(2-Thiazolyl)-1-piperazinyl]-5-thiadiazolyl]-1-methyl-5-nitroimidazole

Beteiligte Stoffe

Rolle	Name	HCID	Einwaage
Edukt	1-(Thiazol-2-yl)piperazine	HCID 911806	—
Edukt	1-[3-(Dimethylamino)propyl]piperazine	HCID 2736234	—
Edukt	2-{2-[4-(3-Dimethylaminopropyl)-1-piperazinyl]-5-thiadiazolyl}-1-methyl-5-nitroimidazole	HCID 21390803	—
Produkt	2-{2-[4-(2-Thiazolyl)-1-piperazinyl]-5-thiadiazolyl]-1-methyl-5-nitroimidazole	HCID 21390853	—

Reaktionsschritte

The preparation of the subject compound is carried out essentially as described for the 2-[4-(3-dimethylaminopropyl)-1-piperazinyl] derivative (Example 35), an equivalent of 1-(2-thiazolyl)piperazine replacing the 1-(3-dimethylaminopropyl)piperazine. After recrystallization from 2-methoxyethanol, the pure compound melts at 297°-300° C.

Herkunft & Nachweise

DOI	10.6084/m9.figshare.5104873.v1
Patentnummer	US03991200
Quelldatensatz	uspto-grants-1976_11
ORD ID	ord-c03975106e50422499cfeb3e916f17df
Quellennotiz	uspto-grants-1976_11