Miconazole → HCID 178521218, Verbindung

HRID 1730218

Reaktionsgleichung

Reaktionsgleichung von HRID 1730218
[Cl:1][C:2]1[CH:24]=[C:23]([Cl:25])[CH:22]=[CH:21][C:3]=1[CH:4]([O:11][CH2:12][C:13]1[CH:18]=[CH:17][C:16]([Cl:19])=[CH:15][C:14]=1[Cl:20])[CH2:5][N:6]1[CH:10]=[CH:9][N:8]=[CH:7]1.[Cl:26][C:27]1[CH:36]=[C:35]([Cl:37])[CH:34]=[CH:33][C:28]=1[CH:29]([OH:32])[CH2:30]Cl>C(#N)C1C=CC=CC=1>[Cl-:1].[Cl:1][C:2]1[CH:24]=[C:23]([Cl:25])[CH:22]=[CH:21][C:3]=1[CH:4]([O:11][CH2:12][C:13]1[CH:18]=[CH:17][C:16]([Cl:19])=[CH:15][C:14]=1[Cl:20])[CH2:5][N+:6]1[CH:10]=[CH:9][N:8]([CH2:30][CH:29]([OH:32])[C:28]2[CH:33]=[CH:34][C:35]([Cl:37])=[CH:36][C:27]=2[Cl:26])[CH:7]=1

Komponenten

4

Edukt 2

HCID 4189MiconazoleHCID 943512,4-Dichloro-alpha-(chloromethyl)benzenemethanol

Produkt 1

HCID 178521218HCID 178521218, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 7505BenzonitrileLösungsmittel

Versuchsvorschrift

4.2 parts of 1-[2,4-dichloro-β-(2,4-dichlorobenzyloxy)phenethyl]imidazole and 3 parts of 2,4-dichloro-α-(chloromethyl)benzyl alcohol are mixed together in 40 parts of benzonitrile and the resulting mixture is stirred at reflux temperature for 3 days. At the end of this period the reaction solvent is evaporated off under reduced pressure to obtain a 1-[2,4-dichloro-β-(2,4-dichlorobenzyloxy)phenethyl]-3-(2,4dichloro-β-hydroxyphenethyl)imidazolium chloride product as residue.

Aufarbeitung

  1. temperatureat reflux temperature for 3 days
  2. customAt the end of this period the reaction solvent is evaporated off under reduced pressure

Quellen und Nachweise

ORD-Eintrag
ord-b8c99004b2fc46d8abdd7b201cc6f99d
Quelldatensatz
uspto-grants-1976_11
Patentnummer
US03991202

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