Water → N-cyclopentyl-2,4,5-trimethylfuran-3-hydroxamic acid

HRID 1730811

Reaktionsgleichung

Reaktionsgleichung von HRID 1730811
Cl.[CH:2]1([NH:7][OH:8])[CH2:6][CH2:5][CH2:4][CH2:3]1.C(=O)([O-])O.[Na+].O.[CH3:15][C:16]1[O:17][C:18]([CH3:25])=[C:19]([CH3:24])[C:20]=1[C:21](Cl)=[O:22]>ClCCl>[CH:2]1([N:7]([C:21]([C:20]2[C:19]([CH3:24])=[C:18]([CH3:25])[O:17][C:16]=2[CH3:15])=[O:22])[OH:8])[CH2:6][CH2:5][CH2:4][CH2:3]1

Komponenten

6

Edukt 4

HCID 962WaterHCID 516892Sodium BicarbonateHCID 145359342,4,5-Trimethyl-3-furancarbonyl chlorideHCID 21496528N-cyclopentylhydroxylamine hydrochloride

Produkt 1

HCID 21496531N-cyclopentyl-2,4,5-trimethylfuran-3-hydroxamic acid

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6344DichloromethaneLösungsmittel2×

Versuchsvorschrift

27.5 Parts of N-cyclopentylhydroxylamine hydrochloride is dissolved in 200 parts of dichloromethane; a solution of 33.6 parts of sodium hydrogen carbonate in 300 parts of water is then added. At room temperature and while stirring thoroughly, 34.5 parts of 2,4,5-trimethylfuran-3-carboxylic chloride is dripped into this mixture. After the mixture has been stirred for 2 hours the dichloromethane phase is separated, dried over anhydrous sodium sulfate and evaporated. There is obtained 36 parts of N-cyclopentyl-2,4,5-trimethylfuran-3-hydroxamic acid in the form of an oil.

Aufarbeitung

  1. customis separated
  2. dry with materialdried over anhydrous sodium sulfate
  3. customevaporated

Quellen und Nachweise

ORD-Eintrag
ord-73b27876e187405da658474c60db9518
Quelldatensatz
uspto-grants-1976_11
Patentnummer
US03993772

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