N,N-dimethyl-2-(4-nitrophenoxy)ethanamine → 4-[2-(Dimethylamino)ethoxy]aniline

HRID 1730916Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1730916
[CH3:1][N:2]([CH3:15])[CH2:3][CH2:4][O:5][C:6]1[CH:11]=[CH:10][C:9]([N+:12]([O-])=O)=[CH:8][CH:7]=1>C(O)C.[Pd]>[CH3:1][N:2]([CH3:15])[CH2:3][CH2:4][O:5][C:6]1[CH:11]=[CH:10][C:9]([NH2:12])=[CH:8][CH:7]=1

Komponenten

4

Edukt 1

HCID 887421N,N-dimethyl-2-(4-nitrophenoxy)ethanamine

Produkt 1

HCID 64846554-[2-(Dimethylamino)ethoxy]anilineAusbeute 90 %

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 23938PalladiumKatalysatorHCID 702EthanolLösungsmittel2×

Versuchsvorschrift

A solution of 42.5g (0.2 mole) of N, N-dimethyl-2-(4-nitrophenoxy)ethanamine in 200 ml of ethanol is divided and reduced in a Parr apparatus using 2g of 5% palladium/charcoal in 50 ml of ethanol for each of the two reactions. The combined mixtures are filtered, the solvent is evaporated and the residue is distilled to give 32.4g (90%) of oil, boiling point 145°-148° C/0.7 mm of Hg. This material solidifies into needles, melting point 48°-50° C.

Aufarbeitung

  1. filtrationThe combined mixtures are filtered
  2. customthe solvent is evaporated
  3. distillationthe residue is distilled

Quellen und Nachweise

ORD-Eintrag
ord-23cedebae6bd41d0afb82b3fd0c59833
Quelldatensatz
uspto-grants-1976_11
Patentnummer
US03994900

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