Z-Thr(But)-Ser(But)-OMe → H-Thr(But)-Ser(But)-OMe

HRID 1731232Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1731232
[NH:1](C(OCC1C=CC=CC=1)=O)[C@H:2]([C:10]([NH:12][C@H:13]([C:20]([O:22][CH3:23])=[O:21])[CH2:14][O:15][C:16]([CH3:19])([CH3:18])[CH3:17])=[O:11])[C@@H:3]([CH3:9])[O:4][C:5]([CH3:8])([CH3:7])[CH3:6]>C(OCC)(=O)C.[Pd]>[NH2:1][C@H:2]([C:10]([NH:12][C@H:13]([C:20]([O:22][CH3:23])=[O:21])[CH2:14][O:15][C:16]([CH3:19])([CH3:18])[CH3:17])=[O:11])[C@@H:3]([CH3:9])[O:4][C:5]([CH3:8])([CH3:7])[CH3:6]

Komponenten

4

Edukt 1

HCID 131710554Z-Thr(But)-Ser(But)-OMe

Produkt 1

HCID 131710555H-Thr(But)-Ser(But)-OMe

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 23938PalladiumKatalysatorHCID 8857Ethyl AcetateLösungsmittel

Versuchsvorschrift

3.27 g of Z-Thr(But)-Ser(But)-OMe in 50 ml of ethyl acetate are hydrogenated in the presence of 0.5 g of palladium on charcoal (10% strength). After the absorption of hydrogen has ceased (1 hour), the catalyst is filtered off and the solution is evaporated. The product, which is obtained as an oil, is a single substance according to thin layer chromatography.

Aufarbeitung

  1. customAfter the absorption of hydrogen
  2. custom(1 hour)
  3. filtrationthe catalyst is filtered off
  4. customthe solution is evaporated
  5. customThe product, which is obtained as an oil

Quellen und Nachweise

ORD-Eintrag
ord-8d1aeb1e520c44deaaf2c3e697668463
Quelldatensatz
uspto-grants-1976_11
Patentnummer
US03994871

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