Trifluoroacetic acid → HCID 131714943, Verbindung
Reaktionsgleichung
CC(C)(OC(CN(C)C(N1CCC[C@H]1C(OCC1C=CC=CC=1)=O)=O)=O)C.FC(F)(F)C(O)=O.[C:35]1(OC)[CH:40]=[CH:39][CH:38]=[CH:37][CH:36]=1.[C:43]([CH2:46][CH2:47][N:48]([CH3:66])[C:49]([N:51]1[CH2:65][CH2:64][CH2:63][C@H:52]1[C:53]([O:55][CH2:56][C:57]1C=CC=CC=1)=[O:54])=[O:50])([OH:45])=[O:44]>>[C:43]([CH2:46][CH2:47][N:48]([CH3:66])[C:49]([N:51]1[CH2:65][CH2:64][CH2:63][C@H:52]1[C:53]([O:55][CH2:56][CH2:57][C:35]1[CH:36]=[CH:37][CH:38]=[CH:39][CH:40]=1)=[O:54])=[O:50])([OH:45])=[O:44]Komponenten
5
Versuchsvorschrift
The ester product from part (c) (2.7 g., 7.17 mmole) is treated for 1.5 hours with 10 ml. of trifluoroacetic acid and 1.6 ml. of anisole. After concentrating to dryness it is triturated with ether-hexane. The crude material is crystallized from ether to yield 2 g. of 1-[[(2-carboxyethyl)methylamino]carbonyl]-L-proline, phenylmethyl ester; m.p. 102°-104°.