Water → 1-(2-Amino-2-methylpropoxy)-2,2,5,5-tetramethylcyclopentane

HRID 1731683

Reaktionsgleichung

Reaktionsgleichung von HRID 1731683
C([NH:8][C:9]([CH3:22])([CH3:21])[CH2:10][O:11][CH:12]1[C:16]([CH3:18])([CH3:17])[CH2:15][CH2:14][C:13]1([CH3:20])[CH3:19])(OC(C)(C)C)=O.O.[OH-].[K+]>FC(F)(F)C(O)=O>[NH2:8][C:9]([CH3:22])([CH3:21])[CH2:10][O:11][CH:12]1[C:16]([CH3:18])([CH3:17])[CH2:15][CH2:14][C:13]1([CH3:20])[CH3:19]

Komponenten

5

Edukt 3

HCID 962WaterHCID 14797Potassium HydroxideHCID 20165736N-Boc-1-(2-amino-2-methylpropoxy)-2,2,5,5-tetramethyl cyclopentane

Produkt 1

HCID 201657551-(2-Amino-2-methylpropoxy)-2,2,5,5-tetramethylcyclopentane

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6422Trifluoroacetic acidLösungsmittel

Versuchsvorschrift

N-Boc-1-(2-amino-2-methylpropoxy)-2,2,5,5-tetramethyl cyclopentane is dissolved in trifluoroacetic acid and stirred overnight. The solution is poured into 0 water and neutralized with 20% aqueous KOH. The mixture is extracted with ethyl acetate, dried over MgSO4, filtered and evaporated to give 1-(2-amino-2-methylpropoxy)-2,2,5,5-tetramethylcyclopentane.

Aufarbeitung

  1. extractionThe mixture is extracted with ethyl acetate
  2. dry with materialdried over MgSO4
  3. filtrationfiltered
  4. customevaporated

Quellen und Nachweise

ORD-Eintrag
ord-6b3416c251544d3a9a38682da2dae55b
Quelldatensatz
uspto-grants-1986_11
Patentnummer
US04622418

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