Propylene Oxide → 1-[4-(3-Fluorophenoxy)phenoxy]propan-2-ol

HRID 1732157Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1732157
[F:1][C:2]1[CH:3]=[C:4]([CH:13]=[CH:14][CH:15]=1)[O:5][C:6]1[CH:11]=[CH:10][C:9]([OH:12])=[CH:8][CH:7]=1.[CH2:16]1[O:19][CH:17]1[CH3:18].C(N(CC)CC)C>C(OCC)C>[F:1][C:2]1[CH:3]=[C:4]([CH:13]=[CH:14][CH:15]=1)[O:5][C:6]1[CH:11]=[CH:10][C:9]([O:12][CH2:16][CH:17]([OH:19])[CH3:18])=[CH:8][CH:7]=1

Komponenten

5

Edukt 3

HCID 6378Propylene OxideHCID 8471TriethylamineHCID 109216164-(3-Fluorophenoxy)phenol

Produkt 1

HCID 137531881-[4-(3-Fluorophenoxy)phenoxy]propan-2-ol

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 3283Diethyl EtherLösungsmittel

Reaktionsbedingungen

Temperatur
90 °C

Versuchsvorschrift

A mixture of 6.13 g of p-(m-fluorophenoxy)phenol, 2.79 g of propylene oxide and 0.12 g of triethylamine is stirred at 90° C. for 18 hours. The cooled mixture is subsequently diluted with 100 ml of diethyl ether and washed successively twice with 50 ml of 2N hydrochloric acid each time, three times with 50 ml of 2N sodium hydroxide each time, with 50 ml of water and with 50 ml of saturated sodium chloride solution. After drying over anhydrous sodium sulfate and evaporation there is obtained 1-[p-(m-fluorophenoxy)phenoxy]-2-propanol of melting point 37°-39° C.

Aufarbeitung

  1. washwashed successively twice with 50 ml of 2N hydrochloric acid each time, three times with 50 ml of 2N sodium hydroxide each time
  2. dry with materialAfter drying over anhydrous sodium sulfate
  3. customevaporation there

Quellen und Nachweise

ORD-Eintrag
ord-7d78d94e419c4f73b0189b78574d9a05
Quelldatensatz
uspto-grants-1986_11
Patentnummer
US04625048

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