Ethyl Bromide → N-Ethyl-N-methyl-2-thiophene methanamine

HRID 1732894

Reaktionsgleichung

Reaktionsgleichung von HRID 1732894
BrCC.[CH2:4]([N:6]([CH2:9][CH3:10])[CH2:7][CH3:8])C.CNC[C:14]1[S:15]C=[CH:17][CH:18]=1>C1(C)C=CC=CC=1.O.C(=O)(O)[O-].[Na+]>[CH2:7]([N:6]([CH3:4])[CH2:9][C:10]1[S:15][CH:14]=[CH:18][CH:17]=1)[CH3:8]

Komponenten

7

Edukt 3

HCID 6332Ethyl BromideHCID 8471TriethylamineHCID 436153N-Methyl-1-(thiophen-2-yl)methanamine

Produkt 1

HCID 12788071N-Ethyl-N-methyl-2-thiophene methanamine

Reagenzien, Katalysatoren, Lösungsmittel 3

HCID 962WaterLösungsmittelHCID 1140TolueneLösungsmittelHCID 516892Sodium BicarbonateLösungsmittel

Versuchsvorschrift

Bromoethane (150 ml), triethylamine (7.3 ml) and N-methyl-2-thiophenemethanamine (21.2 g) were stirred at room temperature in toluene (212 ml) for 4 days. The solution was diluted with water, saturated with sodium bicarbonate and extracted with ethyl acetate. The organic extracts were distilled to give the title compound as an oil (13.6 g) b.p. 46° (16 mm).

Aufarbeitung

  1. extractionextracted with ethyl acetate
  2. distillationThe organic extracts were distilled

Quellen und Nachweise

ORD-Eintrag
ord-2cc545f257c747f1846a3e4260f3340f
Quelldatensatz
uspto-grants-1980_12
Patentnummer
US04239769

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