Malononitrile → HCID 13770581, Verbindung

HRID 1733146Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1733146
N1CCOCC1.[OH:7][CH2:8][C:9](=O)[C:10]([CH3:13])([CH3:12])[CH3:11].[CH2:15]([C:18]#[N:19])[C:16]#[N:17]>CN(C)C=O>[NH2:19][C:18]1[O:7][CH:8]=[C:9]([C:10]([CH3:13])([CH3:12])[CH3:11])[C:15]=1[C:16]#[N:17]

Komponenten

5

Edukt 3

HCID 8010MalononitrileHCID 8083MorpholineHCID 99558361-Hydroxy-3,3-dimethylbutan-2-one

Produkt 1

HCID 13770581HCID 13770581, VerbindungAusbeute 51,8 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6228DimethylformamideLösungsmittel

Versuchsvorschrift

174 g (2 moles) of morpholine were added dropwise to a solution of 232 g (2 moles) of hydroxy-pinacolone and 132 g (2 moles) of malonic acid dinitrile in 500 ml of dimethylformamide, while cooling, in a manner such that the internal temperature did not rise above 40° C. After the reaction had ended, the reaction mixture was stirred into 5 liters of ice-water. The solid product which thereby precipitated was filtered off, washed with water and dried. 170 g of 2-amino-3-cyano-4-tert.-butyl-furan of melting point 86° C. were obtained in this manner.

Aufarbeitung

  1. temperaturewhile cooling, in a manner such that the internal temperature
  2. customdid not rise above 40° C
  3. customThe solid product which thereby precipitated
  4. filtrationwas filtered off
  5. washwashed with water
  6. customdried

Quellen und Nachweise

ORD-Eintrag
ord-8a7eb99a7da64152ab6244d79dd93ab8
Quelldatensatz
uspto-grants-1980_12
Patentnummer
US04240820

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