Hydrochloric Acid → 1-(4-Hydroxy-3-thienyl)ethanone

HRID 1733588Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1733588
[OH:1][CH:2]1[C:6]([C:7](=[O:9])[CH3:8])=[CH:5][S:4][CH2:3]1.S(Cl)(Cl)(=O)=O.Cl>C(Cl)Cl>[OH:1][C:2]1[C:6]([C:7](=[O:9])[CH3:8])=[CH:5][S:4][CH:3]=1

Komponenten

5

Edukt 3

HCID 313Hydrochloric AcidHCID 24648Sulfuryl chlorideHCID 20300157HCID 20300157, Verbindung

Produkt 1

HCID 217161-(4-Hydroxy-3-thienyl)ethanoneAusbeute 77 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6344DichloromethaneLösungsmittel2×

Versuchsvorschrift

2.88 parts of 3-hydroxy-4-acetyldihydrothiophene are introduced into 20 parts by volume of dried methylene chloride; a solution of 1.7 parts by volume of sulfuryl chloride in 20 parts by volume of dried methylene chloride is added in the course of 10 minutes at 0° C. During the reaction, nitrogen is passed in, in order to expel the hydrochloric acid formed. After 30 minutes, the reaction mixture is worked up. The end product is isolated from the reaction mixture by the method described in Example 1c. 2.22 parts (77% of theory) of 3-hydroxy-4-acetylthiophene of melting point 44°-47° C. are obtained.

Aufarbeitung

  1. customDuring the reaction, nitrogen
  2. customformed
  3. customThe end product is isolated from the reaction mixture by the method

Quellen und Nachweise

ORD-Eintrag
ord-36db5b46c01244429e0eb715fea88802
Quelldatensatz
uspto-grants-1980_12
Patentnummer
US04242518

Notizen zur Reaktion

Wird geladen…