Sulfuryl chloride → Methyl 3-hydroxy-5-methylthiophene-2-carboxylate

HRID 1733598Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1733598
[CH3:1][O:2][C:3]([CH:5]1[CH:9]([OH:10])[CH:8]=[C:7]([CH3:11])[S:6]1)=[O:4].S(Cl)(Cl)(=O)=O>C(Cl)Cl>[CH3:1][O:2][C:3]([C:5]1[S:6][C:7]([CH3:11])=[CH:8][C:9]=1[OH:10])=[O:4]

Komponenten

4

Edukt 2

HCID 24648Sulfuryl chlorideHCID 537769093-Hydroxy-5-methyldihydrothiophene-2-carboxylic acid methyl ester

Produkt 1

HCID 587860Methyl 3-hydroxy-5-methylthiophene-2-carboxylateAusbeute 75 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6344DichloromethaneLösungsmittel2×

Versuchsvorschrift

17.4 parts of 3-hydroxy-5-methyldihydrothiophene-2-carboxylic acid methyl ester are dissolved in 100 parts by volume of methylene chloride. 14.9 parts of sulfuryl chloride in 20 parts by volume of methylene chloride are added in the course of 30 minutes at 10° C., whilst passing nitrogen into the mixture. The mixture is then distilled. 12.9 parts (75% of theory) of 3-hydroxy-5-methylthiophene-2-carboxylic acid methyl ester of boiling point 67°-70° C./0.3 mbar are obtained.

Aufarbeitung

  1. distillationThe mixture is then distilled

Quellen und Nachweise

ORD-Eintrag
ord-7618a4e722824172ad79f4d0fac56473
Quelldatensatz
uspto-grants-1980_12
Patentnummer
US04242518

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